Punding in non-demented Parkinson's disease patients: Relationship with psychiatric and addiction spectrum comorbidity.
Identifieur interne : 000222 ( Main/Exploration ); précédent : 000221; suivant : 000223Punding in non-demented Parkinson's disease patients: Relationship with psychiatric and addiction spectrum comorbidity.
Auteurs : Mauro Pettorruso [Italie] ; Alfonso Fasano [Canada] ; Luisa De Risio [Italie] ; Lucia Ricciardi [Royaume-Uni] ; Marco Di Nicola [Italie] ; Giovanni Martinotti [Italie] ; Luigi Janiri [Italie] ; Anna Rita Bentivoglio [Italie]Source :
- Journal of the neurological sciences [ 1878-5883 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Dopamine Agents.
- drug therapy : Parkinson Disease.
- epidemiology : Disruptive, Impulse Control, and Conduct Disorders, Parkinson Disease.
- Aged, Analysis of Variance, Comorbidity, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales.
Abstract
Punding is a stereotyped behavior characterized by an intense fascination with a complex, excessive, non-goal oriented, repetitive activity, associated with dopaminergic replacement therapy (DRT) in patients affected by Parkinson's disease (PD) and with dopamine agonists in several conditions. We studied 25 PD patients with punding behaviors, and compared them to 130 PD controls. The psychiatric evaluation included: the Snaith-Hamilton Pleasure Scale (SHAPS); the SCales for Outcomes in PArkinson's disease-Psychiatric Complications (SCOPA-PC); the Barratt Impulsiveness Scale, Version 11 (BIS-11); the Mood Disorder Questionnaire; the Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS). The occurrence of impulse control disorders (ICDs) was diagnosed through a psychiatric interview. Significantly more punding patients (96% vs. 68%; p<0.01) were in treatment with DA agonists, receiving significantly higher DA agonists levodopa equivalent daily dose (LEDD). Punding behaviors were found to be associated with psychiatric comorbidity, particularly with psychosis and bipolar disorder. In addition, higher anhedonic symptoms were reported by punders. High rate of co-occurring addictive behaviors (pathological gambling, hedonistic homeostatic dysregulation) and ICDs were found. In conclusion, presented data confirm that DRT, in a subset of PD patients, is strongly associated with addiction-like behavioral issues. Punding shares similarities with addictive behaviors and is associated to other psychiatric symptoms involving dopamine system alterations.
DOI: 10.1016/j.jns.2016.02.016
PubMed: 26944176
Affiliations:
- Canada, Italie, Royaume-Uni
- Angleterre, Grand Londres, Latium, Ontario
- Londres, Rome, Toronto
- University College de Londres, Université de Toronto
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Le document en format XML
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Electronic address: mauro.pettorruso@hotmail.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Psychiatry and Psychology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name><affiliation wicri:level="4"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="De Risio, Luisa" sort="De Risio, Luisa" uniqKey="De Risio L" first="Luisa" last="De Risio">Luisa De Risio</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatry and Psychology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Psychiatry and Psychology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ricciardi, Lucia" sort="Ricciardi, Lucia" uniqKey="Ricciardi L" first="Lucia" last="Ricciardi">Lucia Ricciardi</name><affiliation wicri:level="4"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Di Nicola, Marco" sort="Di Nicola, Marco" uniqKey="Di Nicola M" first="Marco" last="Di Nicola">Marco Di Nicola</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatry and Psychology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Psychiatry and Psychology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Martinotti, Giovanni" sort="Martinotti, Giovanni" uniqKey="Martinotti G" first="Giovanni" last="Martinotti">Giovanni Martinotti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience and Imaging, "G. d'Annunzio" University of Chieti-Pescara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, "G. d'Annunzio" University of Chieti-Pescara</wicri:regionArea><wicri:noRegion>"G. d'Annunzio" University of Chieti-Pescara</wicri:noRegion></affiliation></author><author><name sortKey="Janiri, Luigi" sort="Janiri, Luigi" uniqKey="Janiri L" first="Luigi" last="Janiri">Luigi Janiri</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatry and Psychology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Psychiatry and Psychology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neurology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="eISSN">1878-5883</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Comorbidity</term><term>Disruptive, Impulse Control, and Conduct Disorders (epidemiology)</term><term>Dopamine Agents (therapeutic use)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Psychiatric Status Rating Scales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Disruptive, Impulse Control, and Conduct Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Psychiatric Status Rating Scales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Punding is a stereotyped behavior characterized by an intense fascination with a complex, excessive, non-goal oriented, repetitive activity, associated with dopaminergic replacement therapy (DRT) in patients affected by Parkinson's disease (PD) and with dopamine agonists in several conditions. We studied 25 PD patients with punding behaviors, and compared them to 130 PD controls. The psychiatric evaluation included: the Snaith-Hamilton Pleasure Scale (SHAPS); the SCales for Outcomes in PArkinson's disease-Psychiatric Complications (SCOPA-PC); the Barratt Impulsiveness Scale, Version 11 (BIS-11); the Mood Disorder Questionnaire; the Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS). The occurrence of impulse control disorders (ICDs) was diagnosed through a psychiatric interview. Significantly more punding patients (96% vs. 68%; p<0.01) were in treatment with DA agonists, receiving significantly higher DA agonists levodopa equivalent daily dose (LEDD). Punding behaviors were found to be associated with psychiatric comorbidity, particularly with psychosis and bipolar disorder. In addition, higher anhedonic symptoms were reported by punders. High rate of co-occurring addictive behaviors (pathological gambling, hedonistic homeostatic dysregulation) and ICDs were found. In conclusion, presented data confirm that DRT, in a subset of PD patients, is strongly associated with addiction-like behavioral issues. Punding shares similarities with addictive behaviors and is associated to other psychiatric symptoms involving dopamine system alterations.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Latium</li><li>Ontario</li></region><settlement><li>Londres</li><li>Rome</li><li>Toronto</li></settlement><orgName><li>University College de Londres</li><li>Université de Toronto</li></orgName></list><tree><country name="Italie"><region name="Latium"><name sortKey="Pettorruso, Mauro" sort="Pettorruso, Mauro" uniqKey="Pettorruso M" first="Mauro" last="Pettorruso">Mauro Pettorruso</name></region><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><name sortKey="De Risio, Luisa" sort="De Risio, Luisa" uniqKey="De Risio L" first="Luisa" last="De Risio">Luisa De Risio</name><name sortKey="Di Nicola, Marco" sort="Di Nicola, Marco" uniqKey="Di Nicola M" first="Marco" last="Di Nicola">Marco Di Nicola</name><name sortKey="Janiri, Luigi" sort="Janiri, Luigi" uniqKey="Janiri L" first="Luigi" last="Janiri">Luigi Janiri</name><name sortKey="Martinotti, Giovanni" sort="Martinotti, Giovanni" uniqKey="Martinotti G" first="Giovanni" last="Martinotti">Giovanni Martinotti</name></country><country name="Canada"><region name="Ontario"><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ricciardi, Lucia" sort="Ricciardi, Lucia" uniqKey="Ricciardi L" first="Lucia" last="Ricciardi">Lucia Ricciardi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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